Atenolol

 Atenolol Dissertation

Synthesis and Physical Homes of Atenolol

Source: Ali, O., Obaid, R., Saify, Z & Ahmed, S i9000. (2005). Biopharmaceutical Evaluation of Oral Tablet Atenolol (100 and 50 mg) about Local Population. Pakistan Log of Pharmaceutical Sciences, 18(1), 25-32 Atenolol is defined to be a " beta1-selective cardioselective beta-adrenergic radio blocking agent without membrane stabilizing or perhaps intrinsic sympathomimetic activities. Larger doses with this drug prevents the beta 2- adrenoreceptors 1”. Atenolol has the molecular formula of C14H22N2O3. Its molecular mass is 266. several grams and its IUPAC name is (RS)-4-(2-hydroxy-3-isopropylaminopropoxy) phenylacetamide. The melting stage 152-155 levels Celsius, has a dissociation frequent (pKa) of 9. 6th at twenty four degrees Grad. It is soluble in water, ethanol and methanol nonetheless it is insoluble in ether 2 . Atenolol can be produced in two parts. The first activity is with the response of phenol and chemical to form the 4-(hydroxymethyl)phenol the second is treating the 4-(hydroxymethyl)phenol chemical substance with NaCN in hot DMF to create the product of 2-(4-hydroxyphenyl)acetonitrile. After that 2-(4-hydroxyphenyl)acetonitrile will be refluxed with H2O and Ethanol. After the hydrolysis with water and ethanol, this kind of compound will probably be catalysed by using a Pt catalyst which forms the product of acetamide after that condensed with hot piperidine gives 2-[4-(2-oxiranylmethoxy)phenyl]acetamide. Then the oxirane ring of 2-[4-(2-oxiranylmethoxy)phenyl]acetamide is usually opened applying isopropylamine in methanol. The condensation of acetonitrile with epichlorohydrin as ahead of gives the 2-[4-(2-oxiranylmethoxy)phenyl]acetonitrile which is then simply treated with isopropylamine in methanol yielding 2-[4-[2-hydroxy-3-(isopropylamino)propoxy]phenyl]acetonitrile. This kind of compound is hydrolyzed with refluxing ethanol/water catalyzed by a Pt catalyst as ahead of to afford the target acetamide3. Referrals:

1 Atenolol tablet Gathered from...

Recommendations: 1 Atenolol tablet Recovered from http://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=1cc22d45-f09a-49e1-896c-01ef9f80822f#nlm34089-3 (Accessed Apr 15, 2013)

2 Ali, O., Obaid, R., Saify, Z & Ahmed, S. (2005). Biopharmaceutical Evaluation of Oral Tablet Atenolol (100 and 55 mg) in Local Human population. Pakistan Record of Pharmaceutical drug Sciences, 18(1), 25-32

a few Atenolol Synthesis Retrieved by http://homepage.ntlworld.com/bhandari/Imperial/Atenolol/Synthesis.htm (Accessed April 12-15, 2013)


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